Pilot Study to Evaluate the Effect of ENI Patented Whole Grape Extract on Antioxidant Status

Inclusion Criteria: 1. Male or female 18 - 65 years of age 2. If female, subject is not of child bearing potential. Defined as females who have had a hysterectomy or oophorectomy, bilateral tubal ligation or are post-menopausal (natural or surgically with \> 1 year since last menstruation). OR Female subject of childbearing potential must agree to use a medically approved method of birth control and have a negative urine pregnancy test result. Acceptable methods of birth control include: * Double-barrier method (condoms with spermicide or diaphragm with spermicide) * Hormonal contraceptives including oral contraceptives, hormone birth control patch (Ortho Evra), vaginal contraceptive ring (NuvaRing), injectable contraceptives (Depo-Provera, Lunelle), or hormone implant (Norplant System) * Intrauterine devices * Vasectomy of partner (shown successful as per appropriate follow-up) * Abstinence 3. One or more of the following conditions: * Pre-hypertension defined as diastolic blood pressure of 80-89 mmHg and systolic blood pressure of 139 or lower at screening * BMI from 25.0 to 34.9 kg/m2 * Pre-diabetes defined as a fasting plasma glucose from 5.2 to 6.9 mmol/L 4. Subjects who are smokers agree to report smoking habits at each visit and do not plan on changing their smoking habits during the study. 5. Has given voluntary, written, informed consent to participate in the study Exclusion Criteria: 1. Women who are pregnant, breastfeeding, or planning to become pregnant during the course of the trial 2. Subject has any clinically significant medical conditions including cardiovascular disease,hypertension (systolic blood pressure ≥ 140 mmHg, diastolic blood pressure ≥ 90mmHg), diabetes, liver or kidney disease 3. Use of medication for the treatment of hypertension 4. Use of medication for vasodilation, including nitric oxide releasing patches 5. Use of medication for erectile dysfunction 6. Use of medication (prescribed or over the counter) for weight loss 7. Use of statins, fibrates, niacin, or any other medication for the treatment of hypercholesterolemia 8. Use of anticoagulants 9. Use of illicit drugs or history of drug or alcohol abuse with the past 5 years (currently having more than 2 standard alcoholic drinks per day) 10. Use of natural health products (NHPs)/dietary supplements that are known to have significant antioxidant activity within 2 weeks prior to baseline and during the course of the study including but not limited to vitamins A, C, and E, selenium and zinc. 11. Participation in a clinical research trial within 30 days prior to baseline 12. Clinically significant abnormal laboratory results at screening including * AST, ALT and/or bilirubin \> 2 x the ULN * Serum creatinine \>1.5 x the ULN or eGFR \< 60 * hemoglobin \< 140 g/L for males and \< 123 g/L for females 13. Allergy or sensitivity to test product ingredients 14. Individuals who are cognitively impaired and/or who are unable to give informed consent 15. Any other condition which in the Investigator's opinion may adversely affect the subject's ability to complete the study or its measures or which may pose significant risk to the subject