Luna Interbody System for Fusion Trial

Inclusion Criteria: 1. Age 18 - 65 at the time of consent 2. Patient has back pain consistent with symptomatic degenerative disc disease at one level or two contiguous levels from L2-S1 requiring surgical intervention. 3. Patient has had at least 6 months of non-operative care 4. Patient is mentally capable and willing to sign a study-specific informed consent form 5. Patient is willing and able to comply with all study requirements 6. Patient has a score on the back pain visual analog scale (VAS) of ≥ 40 mm 7. Patient has an Oswestry Disability Index (ODI) score of ≥ 30% Exclusion Criteria: 1. DDD affecting \>2 levels 2. Back pain due to causes other than DDD 3. Spine surgery within last 3 months or planned spine surgery within 6 weeks of post study procedure 4. \>Grade 1 spondylolisthesis or retrolisthesis 5. Infection at or close to target disc level 6. Active systemic infection 7. Patient has known osteoporosis 8. Prior interbody fusion at the target level 9. Prior failed interbody fusion at any level 10. Known allergy to device materials 11. Uncontrolled psychiatric illness or severe dementia 12. Pregnant at time of enrollment or considering getting pregnant during study period 13. Any metabolic or other bone disease that could significantly compromise pedicle screw and/or interbody device placement. 14. Any severe illness that would prevent complete study participation 15. Uncontrolled diabetes 16. Current use of chronic steroids (more than equivalent of 10 mg prednisone daily) 17. Contraindication to spinal surgery or general anesthesia 18. Coagulopathy 19. Body mass index \>35 20. Current smoker 21. Known illicit substance abuser 22. Currently participating in another investigational study that could affect responses to the study device