The purpose of the study is to determine the association between acute kidney injury and serum levels symmetrical and asymmetrical dimethylarginine (SDMA/ADMA) and their assumptive influence on mortality, renal function and on arterial stiffness.
Acute kidney injury (AKI) is a frequent complication with severe implications deteriorating overall prognosis. Nitric oxide (NO)-signal transduction plays an important role in mediating renal damage. NO is produced by NO-synthase (NOS) with L-arginine as its substrate. Endogenous L-Arginine derivatives, asymmetric and symmetric dimethylarginines (ADMA/SDMA), inhibit NO-production directly (AMDA) by blocking NOS activity or indirectly (SDMA) by blocking cellular L-Arginine uptake. It is well known that SDMA and ADMA are markers of renal function (SDMA) and cardiovascular risk (ADMA/SDMA) in patients with chronic kidney disease (CKD). Moreover, ADMA and SDMA possibly even trigger cardiovascular risk in patients with CKD. However, there is only little information about the regulation and the influence of ADMA/SDMA in acute kidney injury.
Study Type
OBSERVATIONAL
Enrollment
300
University Hospital of Wuerzburg
Würzburg, Germany
Difference in serum ADMA level between acute kidney injury and renal recovery
Time frame: participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks
Difference in serum SDMA level between acute kidney injury and renal recovery
Time frame: participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks
Associations between ADMA/SDMA serum level and all cause mortality
Time frame: participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks
Associations between ADMA/SDMA serum level and parameters of arterial stiffness
Parameters of arterial stiffness include augmentation index and pulse wave velocity
Time frame: participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks
Associations between ADMA/SDMA serum level and parameters of renal function
Parameters of renal function include serum creatinine and estimated Glomerular Filtration Rate (eGFR)
Time frame: participants will be followed from the time of recruitment to the end of hospital stay, an expected average of 2 weeks
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