The Microcirculation in Acute Myocardial Infarction (Micro-AMI)

University of Bristol50 enrolled

Overview

This study investigates the association between the microvascular resistance at the time of primary percutaneous intervention, with microvascular obstruction on CMR and blood markers of myocardial damage.

Study Type

OBSERVATIONAL

Enrollment

Conditions

STEMI

Interventions

Index of microvascular resistancePROCEDURE

Cardiac magnetic resonanceOTHER

Blood markersOTHER

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \>18 years old * Cardiac symptoms of \> 20 mins chest pain or equivalent. * ECG criteria consistent with STEMI (STEMI) * Proceeding with percutaneous angioplasty * Assent/ consent to the study Exclusion Criteria: * Known allergy to adenosine or gadolinium * Chronic atrial fibrillation * Renal impairment with eGFR \<30 * Contraindication to angiography * Contraindication to CMR (implanted pacemaker/ defibrillator, ferromagnetic metal implant/ injury, claustrophobia, obesity/ too large for CMR scanner) * Cardiogenic shock * Patients with special communication needs or altered consciousness. * Patients who do not give assent/consent to the study

Locations (1)

Bristol Heart Institute

Bristol, United Kingdom

Outcomes

Primary Outcomes

Microvascular obstruction

Microvascular obstruction as a percentage of the left ventricle at 2-4 days.

Time frame: DAy 2-4

Data from ClinicalTrials.gov

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