Lenalidomide and Dexamethasone in Primary Plasma Cell Leukemia

Inclusion Criteria: * Newly diagnosed patients fulfilling the IMWG diagnostic criteria of PPCL * Age \> 18 years * ECOG performance status of 0,1 or 2 * Life expectancy of at least 12 weeks Exclusion Criteria: * Myocardial infarction within 6 months prior to enrollment or uncontrolled angina * Severe uncontrolled ventricular arrhythmias * ECG evidence of acute ischemia or active conduction system abnormalities * Female subjects either pregnant or breast-feeding * Serious medical or psychiatric illness * Total bilirubin greater than 2.0 mg/dL and/or SGOT or SGPT greater than two and a half times normal (unless due to primary malignancy) * History of severe hepatic dysfunction * Active infections or HIV positivity * Uncontrolled insulin-dependent diabetes mellitus * Uncompensated major thyroid or adrenal dysfunction * Hemodialysis or peritoneal dialysis * Renal dysfunction (unless due to primary malignancy; in this case, enrollment at the discretion of the principal investigator) * ECOG performance status of 3 (unless due to primary malignancy; in this case, enrollment at the discretion of the principal investigator)