Physical Training and Cognitive Activity on the Mild Cognitive Impairment (MCI) Patient

Centre Hospitalier Universitaire de Nice5 enrolled

Overview

Regular physical activity is now recognized as a key element of good physical and mental health and this all ages. MAIN GOAL : Evaluate the effectiveness of physical training associated with a cognitive training in improving the cognitive function of patients diagnosed with Mild Cognitive Impairment (MCI). DESIGN : Controlled randomized monocentric and prospective study with clinical benefit for the patient with three groups : one physical training and cognitive exercise group, one physical training without cognitive exercise group and one control group. In agreement with the literature on the effects of physiological stress on cognitive performance, the investigators expect the best cognitive test scores in groups with exercise training compared with controls (35% versus 80% error), and better scores on the MMSE, IALD, depression Scale, Index of Pittsburg sleep quality and quality of Life Questionnaire. Furthermore the investigators hypothesize that this positive effect is greater in the physical training and cognitive exercise group compared with the physical training group only.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Mild Cognitive Impairment Alzheimer's Disease

Interventions

Physical Training and cognitive activity (EPC group)OTHER

The patients of the EPC group will realize 2 weekly sessions of 20 minutes of pédalage. During the exercise, the patients will realize a series of tests of decision-making and perceptive cognitive capacity.

Physical training (EP group)OTHER

The patients of the group (EP) will realize 2 weekly sessions of 20 minutes of pédalage.

control groupOTHER

no physical training and no cognitive activity

Eligibility

Sex: ALLMin age: 40 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed patient MCI (Mild Cognitive Impairment) * Elderly from 40 to 75 years old * MMSE upper to 22 * Affiliated or beneficiary of a national insurance scheme * Medical capacity to the physical proposed activity (filling of the conditions of the Medical certificate of not contraindication in the sport) Exclusion Criteria: * The placed persons under guardianship, under protection of justice, * The private persons of freedom (administrative or judicial) * Nobody already participating in a clinical trial

Outcomes

Primary Outcomes

effectiveness of physical training

Assess the effectiveness of physical training associated with a cognitive training in improving the cognitive functions of patients diagnosed with Mild Cognitive Impairment (MCI). We expect the best cognitive test scores in groups with exercise training compared with controls (35% versus 80% error), and better scores on the MMSE, IALD, depression Scale, Index of Pittsburg sleep quality and quality of Life Questionnaire.

Time frame: up to 3 months

Secondary Outcomes

Cognitive improvement

Assess the cognitive improvement after three months and after cessation of the intervention. Assess the impact of the intervention on the cognitive and behavioral, 3 months after cessation of training with maintenance of physical activity by patients.