Effect of Vitamin E+Selenium on Kidney Function in Controlled Hypotension

Tehran University of Medical Sciences60 enrolled

Overview

The purpose of this study is to determine whether Kidney injury happens in controlled hypotension during brain operations by using Neutrophil Gelatinase Associated Lipocalin ELISA Kit and if so, does VitaminE+Selenium prevent it

NGAL(Neutrophil Gelatinase Associated Lipocalin) is a 25KD protein which bounds with Gelatinase in Neutrophil granules.It is also expressed in epithelial cells of kidney tubules.NGAL increases in ischemic and toxic injuries of kidney. During controlled hypotension in brain operations injury to the kidneys might occur . This study is designed to assess this possibility and evaluate the effect of VitaminE+Selenium on prevention of this problem

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Acute Kidney Injury

Interventions

vitamin E +SeleniumDRUG

vitamin E 400 IU once 8 hrs before operation selenium 150 mic once 8 hrs before operation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * All patients who are candidate for brain surgery under controlled hypotension Exclusion Criteria: * Positive history of renal disease * Positive history of diabetes mellitus, CHF, HTN, Breast cancer, fever, leukocytosis

Locations (1)

Tehran university of medical sciences, Imam Khomeini Hospital, neurosurgery operation room and ward

Tehran, Tehran Province, Iran

RECRUITING

Outcomes

Primary Outcomes

increased amount of urinary or serum NGAL after controlled hypotension

Time frame: from 2 hours to 24 hours after controlled hypotension

Central Contacts

Mahmoodreza Torkaman, resident

CONTACT

0098 917 105 0954 MRZTORKAMAN@yahoo.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.