Forty children with and 40 children without Attention deficit Hyperactivity Disorder (ADHD) receive Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) or placebo via a dietary intervention. Cognitive control functions are measured with functional Magnetic Resonance Imaging (MRI) before and after the intervention. Behavioural change is monitored with behavioural scales.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
QUADRUPLE
Enrollment
79
650 mg EPA + 650 mg DHA daily
Placebo contains mono-unsaturated fatty acids (MUFA) in stead of poly-unsaturated fatty acids (PUFA), same energy value
650 mg EPA and 650 mg DHA daily
Utrecht University Medical Center; Child and adolescent psychiatry
Utrecht, Netherlands
Cognitive control task - functional MRI
Time frame: change over 16 week intervention period (pre/post)
Behavioural scales: - Child Behaviour Checklist (CBCL) / Teacher Report Form (TRF) - Strengths and Weaknesses of ADHD-symptoms and Normal behaviour (SWAN) questionnaire
Time frame: Change over 16 week intervention period (pre/post)
Fatty acids status from cheek cells (swabs)
Time frame: Change over 16 week intervention period (pre/post)
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Placebo contains MUFA in stead of PUFA, same energy value