Effectiveness and Safety of Chinese Medicine to Treat Hand, Foot, and Mouth Disease

Inclusion Criteria: * Clinical diagnosis of severe hand-foot-mouth disease patients according to Hand-Foot-Mouth Disease Treatment Guidelines 2010 issued by China's Ministry of Health; More than 1/3 patients should be diagnosed by etiological examination. * Less than 24 hours of occurrence of fever and/or occurrence of tetter or herpes. * Age of 1-13 years. * Patients or their guardians agree to participate in this study and signed the informed consent form. Exclusion Criteria: * Complicated with other diseases such as neurogenic pulmonary edema, cardiopulmonary failure. * Complicated with other serious primary diseases in organ such as congenital heart disease, chronic hepatitis, nephritis and blood diseases, etc. * With history of allergies on traditional Chinese medicine. * Patients who using glucocorticoids for based diseases. * Patients who having history of hemolysis. * Patients or their guardians suffering from Psychiatric diseases. * Attending other clinical studies on HFMD after diagnosed.