Study to Evaluate the Pharmacodynamic and Pharmacokinetic Effects of LX4211 in Subjects With Type 2 Diabetes and Renal Impairment

Inclusion Criteria: * Adults ≥18 to ≤80 years of age * History of T2DM for at least 6 months prior to screening * Moderate to severe renal impairment and not actively on dialysis * Willing and able to perform self-monitoring of blood glucose * Willing and able to provide written informed consent Exclusion Criteria: * History of type 1 diabetes mellitus, diabetic ketoacidosis (within the previous 6 months), or diabetes resulting from pancreatic disorder or secondary diabetes (from acromegaly and/or Cushing's disease) * Subjects who have received a renal allograft * Subjects expecting to require dialysis or to undergo kidney transplantation within 3 months of study dosing * Presence of active hepatic disease or clinically significant abnormal liver function tests at Screening or planned study Day -1 * Subjects with a history of heart attack, severe/unstable angina, or coronary revascularization procedure within 6 months prior to study Day -2 * History of clinically significant cardiac arrhythmias within 1 year prior to study Day -2 * Subjects with congestive heart failure * Subjects with uncontrolled Stage III hypertension * History of 2 or more emergency room visits, doctors' visits, or hospitalizations due to hypoglycemia within the 6 months prior to planned study Day -2 * History of alcohol or illicit drug abuse within 1 year prior to Screening * History of human immunodeficiency virus (HIV), hepatitis B, or hepatitis C * Major surgery within 6 months prior to planned study Day -2 * History of any malignancy within the last 5 years * Triglycerides \>1000 mg/dL at Screening or planned study Day -1 * History of any serious adverse reaction or hypersensitivity to an SGLT inhibitor * Use of corticosteroids within 2 weeks prior to study Day 1 * Use of any investigational drug within 30 days prior to study Day 1, or investigational protein or antibodies within 60 days of Day 1 * Positive urine pregnancy test at Screening * Positive urine screen for illicit drug abuse at Screening * Prior exposure to LX4211