Prospective Study to Compare a Limited Versus Extended Pelvic Lymphadenectomy During Prostatectomy

Inclusion Criteria: * stamp bioptic secured prostate cancer with intermediate or high risk profile (defined as Gleason-Score 7-10 or PSA \> 10 ng/ml) * locally-operable tumor according to DRU/TRUS * negative bone scan * negative CT abdomen / pelvis * general condition according to Karnofsky \>/= 80% * written consent of the patient * adequate hematological, renal and coagulation physiological functions * Patient compliance and geographic proximity to allow adequate follow-up Exclusion Criteria: * Manifest secondary malignancy * Secured metastasis by histologically or by imaging * Myocardial infarction or stroke within the last 6 months * Existing major cardiovascular (grade III - IV according to NYHA), pulmonary (pO2 \<60 mmHg), renal, hepatic or hematopoietic (eg severe bone marrow aplasia) diseases * Severe active or chronic infections (eg pos. HIV-Ab test, HBs-Ag detection in serum and / or chronic hepatitis) * severe psychiatric disease * prior chemotherapy (allowed is a preoperative antiandrogen therapy ≤ 3 months) * previous pelvic radiotherapy * Patients in a closed institution according to an authority or court decision * People who are in a dependent relationship or working relationship with the sponsor or investigator * simultaneous participation in another clinical trial