Previous studies have demonstrated that Myo-inositol is capable of restoring spontaneous ovarian activity, and consequently fertility, in most patients with PCOS. The aim of our study is to investigate the role of folic acid conteined in the inositol preparation. The study group included 50 patients, randomly allocated to subgroup A (myo-inositol 1500 gr) and subgroup B (myo-inositol 2000 gr + folic acid 200 mcg). The investigation include menstrual pattern and hirsutism score evaluation, hormonal assays, oral glucose tolerance test, euglycemic hyperinsulinaemic clamp and lipide profile at baseline and after six months of treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
50
Catholic University of Sacred Heart
Rome, Italy
number of cycles in six months of therapy
We'll estimate the efficacy of the two treatments on the ovarian function and menstrual pattern.
Time frame: 6 months
effects on oral glucose tollerance test
Time frame: six months
effects on hoormonal assay
Time frame: 6 months
effects oon lipide profile
Time frame: 6 months
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