Atorvastatin Calcium in Preventing Metabolic Syndrome in Prostate Cancer Patients Receiving Androgen-Deprivation Therapy

Inclusion Criteria: * Histologically confirmed prostate cancer, any stage disease allowed Androgen deprivation for treatment or control of prostate cancer including any of the following: * Bilateral orchiectomy * Luteinizing hormone-releasing hormone (LHRH) agonist therapy (e.g., leuprolide, goserelin, bicalutamide, flutamide, or similar agents) with or without antiandrogen therapy * No statin therapy, antihyperlipidemic, lipid-lowering medications, HMG-COA reductase inhibitor, atorvastatin calcium, or LIPITOR ® use * Patients must be willing to give written informed consent, and sign an institutionally approved consent form before performance of any study-related procedure not part of normal medical care based on current diagnosis and clinical condition, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care * Karnofsky Performance Status \>= 70 * Able to adhere to the study visit schedule and other protocol requirements * No serious disease or condition that, in the opinion of the investigator, would compromise the patient's ability to participate in the study * Absolute neutrophil count (ANC) \>= 1000 cells/mm\^3 * Platelet Count \>= 100 mm\^3 * Serum creatinine \< 2.0 mg/dL * Aspartate aminotransferase (AST), alanine aminotransferase (ALT) \< 2 x the upper limits of normal * Hepatic alkaline phosphatase \< 2 x the upper limits of normal Exclusion Criteria: * Treatment with a cytotoxic chemotherapy or participation in any other studies involving investigational or marketed products, concomitantly within 30 days before Day 1 of study treatment; palliative radiation therapy is allowed * Known positive for human immunodeficiency virus (HIV) or infectious hepatitis, type A, B or C or active Hepatitis * Known alcohol and/or any other drug abuse * History of intolerance or hypersensitivity to statins and known hypersensitivity to atorvastatin * Known history of non-low-density lipoprotein (LDL) cholesterol \> 150 mg/dL, peripheral artery disease, coronary heart disease, myocardial infarction (MI) or angina, coronary artery disease or diabetes (as should be receiving statin therapy per current standards); in addition, patients with a known history of smoking, hypertension, family history of myocardial events, and non-LDL \> 100 mg/dL * Any evidence of severe or uncontrolled systemic disease (e.g., unstable or uncompensated respiratory, cardiac, hepatic, or renal disease) as assessed by the investigator * Known cerebrovascular accidents within 6 months before Day 1 of study treatment * Treatment with drugs not permitted by the study protocol or the likelihood of requiring treatment during the study period with drugs which might interfere with the absorption and evaluation of study drugs during the study protocol * Any other clinically significant medical disease or condition laboratory abnormality or psychiatric illness that, in the Investigator's opinion, may interfere with protocol adherence or a subject's ability to give informed consent