Comparison of Perennial and Preseasonal Subcutaneous Immunotherapy

Inclusion Criteria: 1. IgE-mediated seasonal allergic rhinitis with symptoms during the grass and rye pollens season (May, June, July); 2. Symptoms of allergic rhinoconjunctivitis requiring medication during the last season 3. Positive skin prick test to grass and rye pollens only with wheal at least as large as histamine control reaction and diameter \> 5mm; 4. For female patients effective contraception and negative pregnancy test results were necessary. Exclusion Criteria: 1. Previous course of immunotherapy with grass and rye pollens extracts or allergens which are unknown during the last 5 years 2. FEV1 \< 80% of predicted 3. Uncontrolled bronchial asthma according to GINA 4. Non-allergic rhinoconjunctivitis 5. Severe acute or chronic diseases, severe inflammatory diseases 6. Autoimmune diseases, immunosuppression, neoplastic diseases 7. Severe psychiatric and psychological disorders including alcohol or drug abuse 8. Contraindication for application of adrenaline; 9. Treatment with beta-blockers 10. Pregnancy or lactation period 11. Females patients seeking to become pregnant 12. Low compliance.