This trial is conducted in Europe. The aim of this trial is to investigate the pharmacokinetics (how the trial drug is distributed in the body) of NNC172-2021 administered subcutaneously, at two different dose levels, in healthy Japanese subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
8
One injection administered subcutaneously (s.c., under the skin). Injection of maximum 1.2 mL
One injection administered subcutaneously (s.c., under the skin)
Novo Nordisk Investigational Site
Harrow, United Kingdom
Area under the curve from time point 0 to infinity (AUC0-∞) of NNC172-2021
Time frame: Week 5
Maximal concentration of NNC172-2021 (Cmax)
Time frame: Week 5
Time point for maximal concentration (tmax)
Time frame: Week 5
Terminal half-life (t1/2)
Time frame: Week 5
Number of adverse events (AEs)
Time frame: Week 5
Presence of antibodies against NNC172-2021
Time frame: Week 5
Residual tissue factor pathway inhibitor (TFPI) functionality measured by coagulation factor Xa (FXa) generation
Time frame: Week 5
TFPI concentration measured by tissue factor pathway inhibitor (TFPI) enzyme-linked immunosorbent assay (ELISA)
Time frame: Week 5
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