DiaPort Closed-Loop Artificial Pancreas

Inclusion Criteria: * Patient must be aged between 18 (inclusive) and 65 years old * Patient must have been clinically diagnosed with Type 1 diabetes mellitus for at least one year * Patient must have been identified as presenting an indication for the DiaPort® system, i.e. showing poor glucose control under Sc insulin delivery as shown by a sustained HbA1C level \> 8% and/or high blood glucose variability including recurrent hypoglycemic events. Patient will be eligible for the study because he/she will have a DiaPort implanted. * Patient must demonstrate proper mental status and cognition for the study * Patient must be affiliated or beneficiary of a social medical insurance * Patient has signed informed consent form prior to study entry Exclusion Criteria: * Unwilling to perform repeated glucose checks, consume standardized meals, and/or take insulin as instructed * Evidence of cardiovascular event during the previous 6 months, non stabilized retinopathy, or clinically significant screening laboratory abnormalities * Pregnancy, breast feeding, or intention of becoming pregnant * Medical condition requiring use of an acetaminophen-containing medication that cannot be withheld for the study admissions. * Patient is actively enrolled in another clinical trial or was part of study within 30 days or whose annual study income is over 4 500€ * Persons deprived of freedom, adults protected by law or vulnerable persons