Respiratory Muscle Strength in Patients With NMD

University of Florida17 enrolled

Overview

The purpose of this study is to determine if inspiratory muscle strength training (IMST) will impact maximal inspiratory pressure and pulmonary function in patients with neuromuscular disease.

Subjects undergo a 12-week period of inspiratory muscle strength training. Respiratory strength is assessed before and after the training period.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Neuromuscular Disease

Interventions

Threshold PEP or IMT device Phillips-RespironicsDEVICE

The subject will be instructed to take 8-15 deep, forceful breaths through the Threshold device, followed by at least 3 minutes of rest. The process will be repeated 3 more times for a total of 4 sets of 8-15 breaths. IMST will be completed three to five days per week, based upon the subject's daily baseline level of fatigue.

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Confirmed diagnosis of neuromuscular disease * Clinical evidence of impaired pulmonary function Exclusion Criteria: * Above or below age range * No clinical evidence of impaired pulmonary function * No diagnosis of a neuromusuclar disease * Presence of an acute illness at time of study * Participating in other research studies involving investigational drugs * Diagnosis of a primary pulmonary disease * Use of tobacco products

Locations (1)

University of Florida

Gainesville, Florida, United States

Outcomes

Primary Outcomes

Maximal Inspiratory Pressure

The primary endpoints for inspiratory muscle training efficacy will be maximal inspiratory pressure tests, a measure of respiratory strength.

Time frame: Baseline (pre-IMST) and 3 months (post-IMST)

Data from ClinicalTrials.gov

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