Prospective Randomized Clinical Trial of Intravenous Lipids and Cholestasis

Inclusion Criteria: All neonates ≥ 34 weeks gestational age with major GI surgical disorders (Gastroschisis, omphalocele, volvulus, trachea-esophageal fistula, duodenal atresia, jejunal atresia, ileal atresia, hirschsprung's disease, anorectal malformation, intestinal obstruction, and GI perforations) requiring surgery admitted to our NICU within first 72 hours will be eligible for this study Exclusion Criteria: 1. If does not need TPN by 72 hours; 2. Direct hyperbilirubinemia within the first 72 hours after birth; 3. TORCH infections (Toxoplasmosis, CMV, Herpes, Rubella, HIV, etc); 4. Biliary tract disorders leading to direct hyperbilirubinemia; 5. Known metabolic disorders that may be associated with direct hyperbilirubinemia- such as Galactosemia, α-1 antitrypsin deficiency, etc