TheraSpheres Treatment for Unresectable Hepatocarcinoma and Portal Vein Thrombosis

Inclusion Criteria: * 18 yrs of age or older * Diagnosis of Hepatocellular Carcinoma * Portal Vein Thrombosis * ECOG performance \< 2 -\>4 weeks since prior radiation, surgery or chemotherapy. * Life expectancy \> 3 months * Able to provide written informed consent process in accordance with institutional review boards guidelines. Exclusion Criteria: * Contraindications to angiography and selective visceral catheterization. * Evidence of blood flow to the lung from the liver greater than 16.5 mCi * Evidence of any detectable Tc-99m MAA flow to the stomach or duodenum, after application of established angiographic techniques to stop or mitigate such flow. * Significant extrahepatic disease. * Severe liver disfunction of pulmonary insufficiency. * Active uncontrolled infection. * Significant underlying medical or psychiatric illness. * Pregnancy. Patients will be excluded if they have pre-existing diarrhea/illness, or if they have a co-morbid disease or condition that would preclude safe delivery of TheraSphere treatment and place the patient at undue risk.