The purpose of this study is to describe bone status on patients with genetic hemochromatosis, at diagnostic time and his evolution under treatment.
Bone diseases have been recognized recently as complications of genetic hemochromatosis. Further studies are needed to describe the role of iron in bone injuries. The purpose of this study is to describe bone status on patients with genetical hemochromatosis, at diagnostic time and his evolution under treatment.
Study Type
OBSERVATIONAL
Enrollment
100
Angers University Hospital
Angers, France
Brest University Hospital
Brest, France
Nantes University Hospital
Nantes, France
Orleans Regional Hospital
Orléans, France
Bone mineral density
Vertebral and hips Dual energy X-ray Absorptiometry (DXA)
Time frame: Change from baseline in bone mineral density at three years
Predictive value of iron overload on Bone Mineral Density
Time frame: 1 day
Number of vertebral fractures
Time frame: 3 years
Number of peripheral fractures
Time frame: 3 years
Number and location of joint lesions detected by the examination (pain and swelling)
Time frame: 3 years
Determination of genetic polymorphism of BMP 2 and 4
Time frame: Baseline
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Poitiers University Hospital
Poitiers, France
Rennes University Hospital
Rennes, France