Analysis of Cutaneous and Hematologic Disorders by High-Throughput Nucleic Acid Sequencing

Stanford University70 enrolled

Overview

The goal of this study is to identify genetic changes associated with the initiation, progression, and treatment response of response of cutaneous and hematologic disorders using recently developed high-throughput sequencing technologies. The improved understanding of the genetic changes associated with cutaneous and hematologic disorders may lead to improved diagnostic, prognostic and therapeutic options for these disorders.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cutaneous Lymphoma Other Skin Disorders Mycosis Fungoides Cutaneous T-cell Lymphoma

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years of age or older * Patient meets the clinical and/or pathologic criteria for the cutaneous or hematologic disorder being examined. * Patient is willing to provide skin biopsies and five 10 mL tubes of peripheral blood. Exclusion Criteria: \- Less than 18 years of age

Locations (1)

Outcomes

Primary Outcomes

Number of mutations

Identify mutations, changes in DNA copy number, structural rearrangements, or altered coding and non-coding RNA expression

Time frame: 2 years