The Activity of TroVax® Versus Placebo in Relapsed Asymptomatic Ovarian Cancer

Inclusion Criteria: * Aged ≥18 years with histologically or cytologically proven advanced epithelial ovarian carcinoma, fallopian tube carcinoma or primary peritoneal carcinoma * Stage IC1 - III or Stage IVA (pleural effusion only) at diagnosis. (According to new FIGO staging effective 01/01/2014) * Completed cytoreductive surgery during the phase of first-line therapy including removal of bulky tumour masses and adequate surgical staging including a minimum of bilateral salpingo-oophorectomy, hysterectomy and omentectomy * Completed first line platinum-based chemotherapy OR Completed first line platinum-based chemotherapy and second line chemotherapy of any type with complete response to second line treatment according to RECIST 1.1 * Have developed relapse ≥6 months after platinum-based chemotherapy (in the case of second relapse, the disease free interval should also be ≥6 months) * Normal CA-125 following platinum-based chemotherapy * Have developed asymptomatic relapse as defined by: 1. CA125 ≥ 2xULN OR 2. Low volume radiological disease and CA125\>ULN Low volume radiological disease is defined as radiologically visible disease excluding intra-hepatic (parenchymal) liver or splenic metastases, ascites or pleural effusion thought to require drainage within the next 2 months. The following are acceptable: Subcapsular liver and splenic lesions, benign lesions or cysts, any suspicious lesions that may represent metastases have to be confirmed by further imaging to be non-metastatic. * Currently asymptomatic and does not require chemotherapy. * Subject is assumed to be clinically immunocompetent and is free of clinically apparent/active autoimmune disease (i.e. no prior confirmed diagnosis or treatment for autoimmune disease including Systemic Lupus Erythematosis, Grave's disease, Hashimoto's thyroiditis, multiple sclerosis, and rheumatoid arthritis). Note: subjects with type I or type II diabetes mellitus can be included, as can subjects with controlled and rarely flaring rheumatoid disease (defined as recent flare within 6 months prior to randomisation/registration) * Subject has adequate bone marrow function as defined by Haemoglobin ≥ 110 g/L, white cell count ≥ 3.0 x 10\^9/L, Absolute Lymphocyte Count (ALC) ≥ 1.0 x 10\^9/L, Absolute Neutrophil Count (ANC) ≥1.5 x 10\^9/L , Platelet Count ≥ 100 x 10\^9/L and \<400 x 10\^9/L, Monocytes \<0.8 x 10\^9/L (for patients who have undergone previous splenectomy monocyte counts can be \< 1.2 x 10\^9/L) * Adequate end-organ function: plasma creatinine ≤ 2x upper limit of normal, AST and/or ALT ≤ 2x upper limit of normal, Total Bilirubin ≤ 1.5x upper limit normal * ECOG performance status 0-1 * Life expectancy ≥6 months and willing to be available to attend clinic visits for treatment and for follow-up * Ability to give written informed consent * To be treated no later than 14 days from randomisation/registration Exclusion Criteria: * Carcino-sarcoma/MMMT * Cancer related symptoms, or disease recurrence requiring immediate treatment * Patients with low volume radiological disease in any of the following sites at trial entry: * Accumulating ascites thought to require drainage within the next 2 months * Pleural effusion thought to require drainage within the next 2 months * Intraparenchymal Liver and/or splenic metastases * CT scan showing bulky disease requiring chemotherapy, as judged by the investigator * Major surgery/radiation therapy, immunotherapy or chemotherapy completed \< 4 weeks prior to randomisation/registration * Patients who are deemed as being immunosuppressed, receiving \> 4 weeks parenteral or oral steroids, (nasal sprays and inhalers are permitted), or receiving immunosuppressive therapy following transplant * Chronic (≥ 6 months) oral corticosteroid use except when prescribed as replacement therapy in the case of adrenal insufficiency. If previously used for ≥6 months then must have discontinued ≥3 months prior to randomisation/registration. * "Currently active" second malignancy, other than non-melanoma skin cancer. Subjects are not considered to have a "currently active" malignancy if they have completed therapy ≥3 years previously and have no known evidence of residual or recurrent disease * Concomitant use of complementary medicines/botanicals. Supplements and conventional multivitamins are acceptable. * Evidence of significant clinical disorder or laboratory finding which in the opinion of the investigator makes it undesirable for the patient to participate in the trial. No participant should have a serious or uncontrolled intercurrent infection (including those positive for HIV, hepatitis B or C) * Psychiatric illnesses/social situations that limit compliance with protocol requirements * Allergy to egg proteins or history of allergic response to vaccinia vaccines * Prior exposure to TroVax® * Cerebral metastases (known from previous investigations or clinically detectable, surgically resected) * Patients on active treatment as part of another clinical trial