Evaluation of the Efficacy and Safety of Hyaluronic Acid Vaginal Gel to Ease Vaginal Dryness

Inclusion Criteria: * under 70 years old, * had been naturally or surgically postmenopausal for more than 6 months, * had symptoms of vaginal dryness due to various causes and had no contraindications to locally applied estrogen Exclusion Criteria: * unmarried, pregnant and breast-feeding women, * patients with vaginal infections such as trichomonas, * candida and bacterial vaginosis, * patients with breast cancer, uterine cancer or estrogen hormone dependent tumors, * genital bleeding of unknown origin, * patients with acute hepatopathy, embolic disorders, * severe primary disease of the kidney and hematopoietic system * recent malignant tumors