Pharmacokinetics of LCQ908 in Patients With Renal Impairment

Inclusion Criteria: * Individuals with renal impairment only * Estimated Creatinine Clearance (CLcr) by the Cockroft-Gault equation ≤80mL/min; * Mild renal impairment defined as CLcr 50-80 mL/min * Moderate renal impairment defined as CLcr 30-50 mL/min * Severe renal impairment defined as CLcr \<30 mL/min * Healthy subjects only • Estimated CLcr by the Cockroft-Gault equation \>80mL/min Exclusion Criteria: * All Individuals * A past medical history of clinically significant ECG abnormalities or a family history of a prolonged QT-interval syndrome. * Female subjects must be of non child bearing potential or use an effective method of contraception. * Individuals with renal impairment * Renal transplant at any time. * Subjects undergoing any method of dialysis (hemodialysis, peritoneal dialysis) within the last 3 months. * History of clinically significant chronic or recurrent urinary tract infection active and requiring antibiotic treatment within the past 30 days. * Any medication that is contraindicated in moderate or severe renally impaired population * Healthy subjects * History or presence of impaired renal function as indicated by clinically significantly abnormal creatinine or BUN and/or urea values, or abnormal urinary constituents (e.g., albuminuria) * Evidence of urinary obstruction or difficulty in voiding at screening * History or presence of hepatitis B or C and/or positive Hepatitis B surface antigen (HBsAg) or Hepatitis C test result at screening. Other protocol-defined inclusion/exclusion criteria may apply.