Bacterial vaginosis is a common vaginal condition involving a reduction in the amount of Lactobacilli, the normal bacteria colonizing the vagina, and an overgrowth of pathogenic bacteria. The presence of bacterial vaginosis in pregnancy is associated with an increased risk of preterm delivery. After a course of antibiotic treatment, recurrence of bacterial vaginosis has been reported in 10-70% of cases. This study aims to verify if administration of vaginal Lactobacilli may reduce the occurrence rate after antibiotic treatment of bacterial vaginosis during pregnancy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
100
Lactobacillus acidophilus 500 million colony-forming units/tablets. One vaginal tablet daily for 10 days.
One vaginal tablet daily for 10 days.
Ostetricia 1, Azienda Ospedaliera Spedali Civili di Brescia
Brescia, Italy
RECRUITINGVaginal lactobacillus recolonization
Time frame: 3-5 weeks
Recurrence rate of bacterial vaginosis
Time frame: 3-5 weeks
Preterm delivery <37 weeks
Time frame: within 43 weeks of gestation
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