Drug Eluting Balloon in Peripheral Intervention for In-Stent Restenosis

Inclusion Criteria: * age\>18 years * intermittent claudication (Fontane III or IV) * angiographic stenosis\>50% or occlusion of superficial femoral-popliteal artery\>40mm, previously treated with nitinol stent implantation, with at least one below-knee vessel to the ankle Exclusion Criteria: * allergy to Paclitaxel * contraindication for combined antiplatelet treatment * life expectancy \<1 year * hypersensitivity or contraindication to one of the study drugs * lack of consent * need for amputation * angiographic evidence of stent fracture