FMRI of Stress and Addictive Disorders

Inclusion Criteria: * Between ages 13-50 years old (adolescents 13-17 years old) * Able to read and write. * COCAINE DEPENDENT SUBJECTS: meet DSM-IV criteria for cocaine dependence; report current cocaine use of at least once a week or more; confirmation of cocaine use via positive urine toxicology screen during initial assessments and upon admission to the CNRU. * OPIOID DEPENDENT SUBJECTS: meet DSM-IV criteria for opiate dependence and are participating in substance abuse treatment including pharmacotherapy for opioid dependence. * ALCOHOL DEPENDENT SUBJECTS: meet DSM-IV criteria for alcohol dependence and are currently abstinent from alcohol as documented by substance abuse treatment participation. * HEALTHY CONTROLS: negative urine toxicology screens during intake appointments indicating no history of current or past dependence on alcohol or illicit drug use. * Healthy adolescent boys and girls, with no medical or psychiatric conditions; * WOMEN: have a regular menstrual cycle. Exclusion Criteria: * CONTROLS: lifetime or current history of any substance abuse/dependence (excluding nicotine). * Regular use of any psychoactive drugs including anxiolytics and antidepressants. * Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, liver, thyroid pathology; subjects on medications for any medical condition will be excluded. * Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded including subjects who work as welders. * Women on oral contraceptives, peri- and post-menopausal women, and pregnant or lactating women (as alterations in stress response are associated with these states). * IQ below 75