The current study will assess the real - life effectiveness of adalimumab in the management of articular and dermatological manifestations of moderate to severe Psoriatic Arthritis (PsA).
Study Type
OBSERVATIONAL
Enrollment
483
Change in the Disease Activity Score - 28 (DAS-28)
The DAS - 28 is calculated using the number of swollen (SJC) and tender (TJC) joints out of 28, the erythrocyte sedimentation rate (ESR) and the patient's global assessment of disease activity using a 100 mm visual analogue scale (VAS)
Time frame: Every 3 months up to 6 months, then every 6 months up to 24 months
Duration of Morning Stiffness (min)
This is ascertained by the treating physician during the patient assessment and is measured in minutes
Time frame: Every 3 months up to 6 months, then every 6 months up to 24 months
Dermatology Life Quality Index (DLQI)
This is a self-administered questionnaire comprised of 10 items assessing a patient's skin and problems associated with skin disease. The 10 questions in the DLQI converge into six domains that measure symptoms and feelings, daily activities, leisure, work and / or school, personal relationships and satisfaction with treatment.
Time frame: Baseline, month 6, month12, month 24
Health Assessment Questionnaire - Disability Index (HAQ-DI)
Self-administered questionnaire measuring the patient's functional ability during the last week.
Time frame: Every 3 months up to 6 months, then every 6 months up to 24 months
Patient Global Assessment of Disease Activity (VAS and 5 Point Scale)
A 100 mm VAS with 0 indicating lowest disease and 100 highest disease activity and a five point Likert Scale (0 - 4) that is completed by the patient at the physician's office
Time frame: Every 3 months up to 6 months, then every 6 months up to 24 months
Physician Global Assessment of Disease Activity (VAS and 5 Point Scale)
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Pont, Cranbrook, BC, CA /ID# 69120
Cranbrook, British Columbia, Canada
Dr. Barbara T. Blumenauer Inc. /ID# 75393
Kamloops, British Columbia, Canada
Hudson, Kamloops, Canada /ID# 69104
Kamloops, British Columbia, Canada
Dr. Maqbool R. Sheriff Inc. /ID# 69125
Nanaimo, British Columbia, Canada
Carmi Medical Clinic /ID# 69128
Penticton, British Columbia, Canada
Dr. J. Antonio Avina-Zubieta /ID# 71035
Richmond, British Columbia, Canada
Dr. Alfonso Verdejo Inc. /ID# 69131
Vancouver, British Columbia, Canada
Dr. Milton F. Baker Inc. /ID# 69085
Victoria, British Columbia, Canada
Manitoba Clinic /ID# 69113
Winnipeg, Manitoba, Canada
Nexus Clinical Research /ID# 45622
St. John's, Newfoundland and Labrador, Canada
...and 31 more locations
This is a 100 mm VAS with 0 indicating lowest disease and 100 highest disease activity a five point Likert Scale (0 - 4) that is completed by the physician during the patient examination
Time frame: Every 3 months up to 6 months, then every 6 months up to 24 months