A Biomarker and MRI Study on Troponin Release After Exercise in Hypertrophic Cardiomyopathy

Inclusion Criteria: * Patients with an echocardiographically proven hypertrophic cardiomyopathy according to the ESC guidelines or individuals with a HCM associated mutation without the clinical characteristics of hypertrophic cardiomyopathy (pre-clinical HCM patients); * Age ≥ 18 years; * Able to comply with the protocol; * Written informed consent. Exclusion Criteria: * Known significant epicardial coronary artery disease; * Patients with LVH in the clinical setting of other disorders that explain the myocardial hypertrophy (amyloidosis, MELAS, Anderson-Fabry, WPW etc.); * Heart failure NYHA class III-IV; * Patients with known hemodynamic instability or syncope during exercise due to left ventricular outflow gradient or occurrence of ventricular arrhythmia; * History of PTSMA (percutaneous transluminal septal myocardial ablation) or Morrow myectomy; * Patients not able to complete a bicycle test; * Any contraindication to MR imaging (MR imaging is not obligatory for assessment of the primary objective, therefore relative exclusion criterion); * Recent (within 30 days) admittance to the hospital for any cardiac reason (myocardial infarction, heart failure, cardiac arrhythmia, etc.); * Severe renal insufficiency (eGFR \< 30 ml/min); * Any other condition which, in the opinion of the investigator, may pose a significant hazard to the subject if he or she participates in the present study.