The study aims at describing the acute and subacute changes after Roux-en-Y (RYGB) gastric bypass in insulin secretion from the beta cell and glucagon secretion from the alpha cell as well as the stimulatory effect of the incretins on the pancreatic islets. RYGB is a bariatric procedure that changes the gastrointestinal anatomy and has been demonstrated to cause remission of type 2 diabetes shortly after the operation, before any significant weight loss. The altered transit of nutrient through the gastrointestinal tract after the operation is thought to play a key role in this remission and studies have shown significant changes in the secretion of gut hormones, namely the incretin hormone glucagon-like peptide-1 (GLP-1). However it is unknown whether the secretory function of the pancreatic islets as well as the stimulatory effect of the incretin hormones is changes postoperatively.
Study Type
OBSERVATIONAL
Enrollment
11
Dpt. of Endocrinology (215) at Hvidovre Hospital
Hvidovre, Copenhagen, Denmark
Change in beta cell function
Change in first and second phase insulin response, disposition index, and acute insulin secretion in response to a non-glucose stimulus
Time frame: Before and 1 week and 3 months after surgery
Insulinotropic effect of incretin hormones
Change in first and second phase insulin response during GLP-1 and GIP infusion compared to saline
Time frame: Before and 1 week and 3 months after surgery
Change in alpha cell function
Change in glucagon secretion in response to glucose and non-glucose stimuli
Time frame: Before and 1 week and 3 months after surgery
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