Efficacy of Sofosbuvir With Ribavirin Administered Pre-Transplant in Preventing Hepatitis C Virus (HCV) Recurrence Post-Transplant

Inclusion Criteria: 1. Willing and able to provide written informed consent 2. Males or females, age \> 18 years old 3. Males must agree to consistently and correctly use a condom while their female partner agrees to use an approved form of birth control from the date of screening until 7 months after their last dose of ribavirin. 4. Confirmation of chronic HCV infection documented by at least one measurement of serum HCV RNA above the LLOQ measured at screening, and at least one of the following: * Positive anti-HCV antibody test, HCV RNA or HCV genotyping test at least 6 months prior to the baseline/Day 1 visit together with positive HCV RNA test and anti-HCV antibody at the time of screening, or * Positive HCV RNA test and anti-HCV antibody test at the time of screening together with either a liver biopsy consistent with chronic HCV infection (or a liver biopsy performed before enrollment with evidence of chronic HCV infection, such as the presence of fibrosis) 5. HCV RNA \> 10\^4 IU/mL at screening 6. Patients meeting the MILAN criteria undergoing liver transplant for HCC secondary to HCV with a MELD of \< 22 and a HCC weighted MELD of ≥ 22. 7. Child-Pugh Score (CPT) ≤ 7 8. Planned management of the subject to meet United Network for Organ Sharing (UNOS) criteria, with imaging studies made available for review if required. 9. Has not been treated with any investigational drug or device within 30 days of the screening visit. Exclusion Criteria: 1. Females of child-bearing potential who is pregnant or nursing 2. Prior exposure to a direct-acting antiviral targeting the HCV nonstructural (NS)5B polymerase 3. Any transplant patient who has agreed to a liver transplant from a live donor. 4. Participants requiring planned induction therapy with biologics posttransplantation or with a posttransplantation immunosuppressive regimen not consistent with the following within the first 12 weeks posttransplant: * Solumedrol/Prednisone (tapering over approximately 7 days) * Tacrolimus (maintaining a serum level of 5 12 ng/mL) * Mycophenolate mofetil (up to 2 g/day) * Introduction of new maintenance immunosuppressants different from the above list is disallowed except in consultation during the first 12 weeks posttransplant 5. Current, uncontrolled ascites, variceal hemorrhage, hepatic encephalopathy, hepatorenal syndrome and hepatopulmonary syndrome, among other signs of decompensated cirrhosis. 6. Chronic liver disease of a non-HCV etiology (eg, hemochromatosis, Wilson's disease, alpha-1 antitrypsin deficiency, cholangitis) 7. Infection with hepatitis B virus (HBV) or HIV 8. Contraindications to RBV therapy 9. Chronic use of systemically administered immunosuppressive agents (eg, prednisone equivalent \> 10 mg/day) in the pretransplant treatment period. 10. History of previous solid organ transplantation 11. Evidence of renal impairment (CLcr \< 60 mL/min) calculated by the Cockcroft-Gault equation. 12. History or current evidence of psychiatric illness, immunologic disorder, hemoglobinopathy, pulmonary or cardiac disease, porphyria, or poorly controlled diabetes, cancer other than HCC, or a history of malignancy that in the opinion of the investigator makes the patient unsuitable for the study. Patients with clinical signs or symptoms of acute pancreatitis with elevated lipase (at Screening or during the screening period) 13. Known hypersensitivity to RBV, the study investigational medicinal product, the metabolites, or formulation excipients 14. History of having received any systemic antineoplastic (including sorafenib) or immunomodulatory treatment (including radiation) within 6 months prior to the first dose of study drug or the expectation that such treatment will be needed at any time during the study (excluding a local regional therapy such as TACE). 15. Treatment with Transcatheter arterial chemoembolization (TACE) or radio frequency ablation (RFA) within 30 days prior to the first dose. 16. Participation in a clinical study with an investigational drug, biologic, or device within 3 months prior to first dose administration at the baseline/Day 1 Visit.