Peri-operative Prediction of Prolonged Stay in the Cardiac Intensive Care Unit for Adult Cardiac Surgery

Thepakorn Sathitkarnmanee164 enrolled

Overview

The purpose of this study is to create a model using intra-operative modified SOFA score and peri-operative clinical factors to predict prolonged stay in the cardiac intensive care unit (CICU) for adult cardiac surgery with heart-lung machine

Cardiac surgery using cardiopulmonary bypass (CPB) is commonly associated with a systemic inflammatory response that exacerbates peri-operative life-threatening complications and multiple organ dysfunction syndromes. These features can prolong the stay in the CICU. Many peri-operative clinical risk factors contribute to those adverse outcomes resulting in prolonged CICU stay. If the investigators can create a model to identify the effects of these intra-operative clinical risk factors to prolonged CICU stay

Study Type

OBSERVATIONAL

Enrollment

164

Conditions

Heart; Dysfunction Postoperative, Cardiac Surgery Cytokine Release Syndrome

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients who had undergone elective cardiac surgery with CPB Exclusion Criteria: * under 18 years of age * needing emergency surgery * needing intra-aortic balloon pump

Locations (3)

Queen Sirikit Heart Cenrter

Khon Kaen, Changwat Khon Kaen, Thailand

Queen Sirikit Heart Center

Khon Kaen, Changwat Khon Kaen, Thailand

Queen Sirikit Heart Center

Khon Kaen, Thailand

Outcomes

Primary Outcomes

Adjusted odds ratio of peri-operative clinical risk factors in prolonged CICU patients

Blood samples were collected for cytokines investigation and leukocyte counts. Clinical scoring systems , major peri-operative clinical risk factors were calculated and recorded at each time point. Univariate odds ratio were calculated for each factors for prolonged CICU stay. Those significant factors were included in logistic regression model for analysis of adjusted odds ratios. Then, a model for prolonged CICU stay is constructed.

Time frame: 24 hours after CPB

Data from ClinicalTrials.gov

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