Pharmacokinetics Of Tigecycline In Morbidly Obese Subjects

Inclusion Criteria: Subjects fulfilling the following criteria will be eligible: 1. males and females, 18 to 50 years of age; 2. non-smoking or light-smoking (≤ 5 cigarettes per day) volunteers; 3. Body mass index: 18.50-24.99 kg/m2 (normal weight) or ≥ 40 kg/m2 (obese class III); 4. female subjects of childbearing potential (self-reported) either surgically sterilized, using an effective method of contraception (diaphragm, cervical cap, condom) or agree to abstain from sex from time of prestudy screening, during entire study period and 1 month following the study period Exclusion Criteria: 1. history of significant hypersensitivity reaction to any components of Tygacil®; 2. history of significant clinical illness requiring pharmacological management; 3. history of blood donation in the past eight week period; 4. abnormal serum electrolyte or complete blood count requiring further clinical work-up; 5. transaminases (AST or ALT) \> 2.5 x upper limit of normal; 6. subjects with stage 4 or 5 chronic kidney disease; 7. positive serum pregnancy test (if female); 8. abnormal electrocardiogram (ECG) as judged by study physician; 9. unable to tolerate venipuncture and multiple blood draws; 10. clinically significant abnormal physical examination defined as a physical finding requiring further clinical work-up; 11. unable to independently provide a written informed consent.