Iodine therapy is the best treatment for graves disease.Most patients receive methimozale prior to radio-iodine treatment. This may decrease treatment response to iodine therapy. Some physicians advice to discontinue methimazole 3 days before radioiodine therapy and others prefer longer off - methimazole period which bothers most patients. This study aimed to evaluate optimum time for methimazole discontinuation in graves disease.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
150
Methimazole was stopped 24-48 before radio-iodine therapy
methimazole discontinued 49-72 hours before radioiodine treatment
methimazole discontinued 73-168 hours before radio-iodine treatment
Mashad University of Medical Sciences
Mashhad, Khorasan Razavi, Iran
thyroid function tests over one year after radioiodine therapy
thyroid function test may change over one year . In order to consider the patients as cured ,thyroid function tests should reveal hypothyroidism or euthyroidism . In order to rule out temporary hypothyroidism the tests should be repeated after 6 months of radioiodine therapy.
Time frame: months 1 , 3 ,6,9,12
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