The overall goal of the PROBIT study is to investigate the influence of a randomized breastfeeding promotion intervention designed to increase the duration and exclusivity of breastfeeding ("the breastfeeding promotion intervention") on the development of maternal and child health outcomes. The hypothesis is that randomization to the intervention will be associated with lower child adiposity, lower risk of asthma and atopy, improved lung function, and improved cognitive outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
17,046
Breastfeeding promotion and support according to the World Health Organization's Baby Friendly Hospital Initiative
Maternal and Child Health Center
Minsk, Belarus
Gastrointestinal tract infection
Occurrence of 1 or more episodes of gastrointestinal tract infection
Time frame: 12 months of age
Maternal adiposity
Time frame: 6.5 and 11.5 years postpartum
Child adiposity
Time frame: Throughout childhood
asthma
Time frame: 6.5 and 16 years
cognition
Time frame: 6.5 and 16 years
dental caries
Time frame: 6.5 years
child behavior
Time frame: 6.5 years
vision
Time frame: 16 years
lung function
Time frame: 16 years
IGF-1
IGF from dried bloodspots
Time frame: Age 11.5 years
child height
Research measures of length/height
Time frame: throughout childhood
adiponectin
adiponectin from dried bloodspot
Time frame: age 11.5 years
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Apo A1
Apo A1 in dried bloodspots
Time frame: Child age 11.5 years
glucose
fingerstick glucose measured by glucometer
Time frame: child age 11.5 years
insulin
insulin measured on dried blood spots
Time frame: child age 11.5 years
Apo B
Apo B measured in dried blood spots
Time frame: Child age 11.5 years
Child blood pressure
Research measures of blood pressure at ages 6.5, 11.5 and 16 years
Time frame: throughout childhood
Maternal blood pressure
Research measure of maternal blood pressure
Time frame: 11.5 years postpartum
Child metabolic syndrome
Time frame: Age 11.5 years
Child growth
Growth in weight, length, weight for length, BMI, and other measures
Time frame: Throughout childhood
Respiratory tract infections
Number of respiratory infections, from review of medical record
Time frame: to age 12 months and throughout childhood
Atopic Eczema
Eczema from review of medical record, parent report,and direct examination
Time frame: Throughout childhood
Atopy
Skinprick tests for allergy
Time frame: Age 6.5 years
Eating Attitudes
Children's Eating Attitudes Test (ChEAT) Questionnaire
Time frame: Age 11.5 years