Efficacy of Nonsteroidal Anti-inflammatory Drugs in Treatment of Moderate and Severe Dry Eye Disease

Inclusion Criteria: * moderate to severe dry eye syndrome * tear film breakup time \>0 second and ≤5 seconds,or schirmer test(no anaesthesia)≥2mm/5min and ≤5mm/5min * corneal staining≥3 scores Exclusion Criteria: * allergic to any composition of the drugs under experiment * previous use of anti-inflammatory drugs or immunosuppressive agent * viral,bacterial or fungal infection of the eye * eyelid anomaly * glaucoma or high IOP * significant meibomian gland dysfunction