Change in Brain Metabolism and Cognitive Function by Aripiprazole

Seoul National University Hospital15 enrolled

Overview

Dopamine receptor occupancy and brain metabolism were measured using positron emission tomography after the administration of aripiprazole. Working memory performance was also measured using N-back task. The investigators explored the relationship between changes in brain metabolism and working memory performance.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Antipsychotics Cognition Brain Metabolism Dopamine Receptor Occupancy

Interventions

AripiprazoleDRUG

single oral administration of aripiprazole

Eligibility

Sex: MALEMin age: 19 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy volunteers * right-handed Exclusion Criteria: * any significant abnormality on routine lab * any psychiatric disease

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Reaction time of correct response in N-back task

Time frame: 48 hrs after the administration of aripiprazole

Data from ClinicalTrials.gov

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