This is a randomised controlled trial that will be conducted in eastern Thailand in a group of schools with approximately 2,000 students aged 7-15 years. Pre-fabricated school uniforms will be commercially treated to ensure consistent high quality of insecticide impregnation with permethrin. A double-blind randomised cross-over trial at the school level will cover two dengue transmission seasons.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
1,825
commercial permethrin insecticide impregnation of clothing before transmission season
normal washing of school uniforms, without permethrin insecticide impregnation
Centre of Excellence for Vectors and Vector-Borne Diseases, Mahidol University
Salaya, Thailand
insecticide:placebo incidence rate-ratio (per 1,000 person-years) of laboratory-confirmed dengue cases in school-aged children
Schools are cross-over randomised to insecticide-treated or untreated (placebo) school uniforms, and so the primary outcome is the rate-ratio of dengue fever cases in school children, compared between these two groups.
Time frame: up to 2 years
comparison between intervention and placebo groups of number of serious skin reactions to insecticide-treated uniforms
Time frame: up to 2 years
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