RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. It may also help doctors find better ways to treat cancer. PURPOSE: This research trial studies genes in samples from patients with limited and advanced diffuse large B-cell lymphoma.
OBJECTIVES: * To determine the proportion of the cell of origin subtypes (germinal center B-cell-like \[GCB\] vs non-GCB) and expression levels of prognostic genes previously identified in diffuse large B-cell lymphoma (DLBCL) in patient biopsy samples from SWOG trials of limited- and advanced-stage DLBCL, and to assess the association between the results and progression-free survival (PFS). * To assess the association between these marker results and overall survival (OS). OUTLINE: Archived formalin-fixed paraffin-embedded tissue are analyzed for gene expression profile by quantitative nuclease protection assay (qNPA) and immunohistochemical analyses. Results are then compared with each patient's progression-free survival and overall survival.
Study Type
OBSERVATIONAL
Enrollment
397
Proportion of GCB phenotype among limited-stage vs advanced-stage patients
Time frame: Retrospectively
Differences in PFS between limited- and advanced-stage patients with the GCB and non-GCB phenotypes
Time frame: Retrospectively
Association between GCB markers and OS
Time frame: Retrospectively
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.