The purpose of this study is to determine whether pretarsal and preseptal techniques of Botulinum toxin type A injection have any effect on tear functions.
Botulinum toxin type A has been used for hemifacial spasm since 1986. of Botulinum toxin type A can be subcutaneously injected at pretarsal or preseptal portion of orbicularis muscle. Blepharoptosis has been reported less frequently with pretarsal technique, however dry eye was noticed in one patient treated with pretarsal botulinum toxin type A for cosmetic purpose.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
26
botulinum toxin type A (Botox)2.5 units, 5 points
Botulinum toxin type A 2,5 units, 5 points
Khon Kaen University
Muang, Changwat Khon Kaen, Thailand
tear break up time
unit of measure; minutes
Time frame: change from baseline in tear break up time at 12 weeks
schirmer's test
units of measurement; millimeters
Time frame: change from baseline of schirmer's test at 12 weeks
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