Low intensity shockwaves have been proven in animal studies to induce local growth of new blood vessels from existing ones. The hypothesis of this study is that shockwave therapy could improve the symptoms of patients with refractory angina not amenable to revascularization with angioplasty or bypass surgery.
Low intensity shockwaves (1/10 the ones used in Lithotripsy) are delivered to myocardial ischemic tissue. Shockwaves are created by a special generator and are focused using a shockwave applicator device. The treatment is guided by standard echocardiography equipment. The shockwaves are delivered in synchronization with Patient R-wave to avoid arrhythmias. The treatment is painless. At first, the patient undergoes stress- SPECT testing to identify the ischemic areas. Following that, the same area is localized by the ultra-sound device and the shockwaves are focused to the ischemic area. Several treatments are required for optimal results.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Energy Density - 0.09 mJ/mm2
KMH Cardiology & Diagnostic Centers
Ontario, Canada
Time to Angina
Change in time to angina using the modified Bruce exercise test from baseline to the 6 moths post baseline assessment
Time frame: 6 months
Change in SPECT
The change in perfusion in pharmacological induced stress SPECT test (at rest and at stress) from baseline to 6 months post baseline (17 segments model).
Time frame: 6 months
Change in AP-CCS
The AP CCS Stage at the 6 months post baseline.
Time frame: 6 months
Total Exercise time
The change in Total Exercise Time (ETT) from baseline to 6 months post baseline.
Time frame: 6 months
Number of angina attacks (patient diary)
The change in the number of angina attacks from baseline to 6 months post baseline. The number of attacks per week will be documented.
Time frame: 6 months
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