Therapeutic Efficacy and Safety of Palonosetron in Treatment of Postoperative Nausea and Vomiting

Inclusion Criteria: * 19 years and older, younger than 70 years old * American society of Anesthesiologists physical status classification I to III * those who undergo laparoscopic gynecologic, abdominal or other surgery under general anesthesia * surgery for which anesthesia is expected to last at least 30 minutes * if a subject has or may develop prolongation of cardiac conduction intervals, particularly corrected QT interval, he/she may be enrolled at the discretion of the investigator. Exclusion Criteria: * known hypersensitivity/ contraindication to 5-hydroxytryptamine antagonists or study drug excipient * inability to understand or cooperate with the study procedures as determined by the investigator * women who are pregnant, nursing or planning to become pregnant, are not using effective birth control, or that have had a positive serum pregnancy test within 7 days prior to surgery day 1. * has received any investigational drug within 30 days before study entry * having taken any drug with potential antiemetic efficacy within 24 hour prior to anesthetic procedures. * any vomiting, retching, or nausea in the 24 hours preceding the administration of anesthesia * known or suspected current history of alcohol abuse or drug abuse. * any condition, which in the opinion of the investigator would make the subject ineligible for participation in the study