Efficacity of rTMS in Alcohol Dependance

Institut National de la Santé Et de la Recherche Médicale, France13 enrolled

Overview

Prior research in substance dependence has suggested potential anti-craving effects of repetitive transcranial magnetic stimulation (rTMS) when applied to the dorsolateral prefrontal cortex (DLPFC). The aim of our study was to investigate the effect of high frequency rTMS of the left dorsolateral prefrontal cortex compared to sham stimulation on craving and alcohol consumption. 150 detoxified patients are randomized either to a high frequency rTMS over the left DLPFC (n = 75) or a sham stimulations (n = 75). Alcohol craving is determined with the Obsessive Compulsive Drinking Scale. Patients are allocated to active and sham rTMS in a 1: 1 ratio, such that 75 patients received active and 75 patients sham rTMS to the left DLPFC (10 Hz frequency, total 10 sessions). The Alcohol Craving Questionnaire (ACQ-NOW) and the Obsessive Compulsive Drinking Scale (OCDS) are administered to measure the severity of alcohol craving at baseline, after the last rTMS session and day 15, M1, M3, M6 after. Alcohol drinking is evaluated with Timeline Followback (TLFB).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Alcohol Dependance

Interventions

rTMS (repetitive transcranial magnetic stimulation)OTHER

Frequency (10hz) 120% motor threshold 10 sessions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of alcohol dependence syndrome according to DSM-IV criteria * Detoxified inpatients hospitalised for Alcohol Withdrawal for more than one week * Giving written informed Exclusion Criteria: * Left-handed patients at the time of inclusion. * Age \< 18 years * Withdrawal Assessment (CIWA-Ar) scores of \> 5 * Patients with major medical or neurological disorders or with a pacemaker or metal in any part of the body were excluded from the study.

Locations (1)

Louis Mourier Hospital

Colombes, France

Outcomes

Primary Outcomes

Superiority of left rTMS (DLPFC)on reduction of alcohol consumption in AD patients compared to sham rTMS

Evaluation of the intensity of craving (AUQ, Borg analogic scale, OCDS) and total day with no alcohol use measured with TLFB at Day 0, Day 5, Day 15, Month1 , Month3 and Month6 in AD outpatients.

Time frame: Patients will be followed during 6 month

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.