Genetic Influence on Statin Pharmacodynamics

Ohio State University

Overview

The study intends to investigate whether genetics influence how individuals respond to statins (clinical outcomes and changes in carotid intimal media thickness)

Study Type

OBSERVATIONAL

Conditions

Hyperlipidemia Hypercholesterolemia Dyslipidemia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * recently (within past 3 months) started taking atorvastatin, lovastatin, or simvastatin Exclusion Criteria: * concomitant uses of medications, supplements, or OTCs known to interfere with statin metabolism

Locations (1)

Ohio State University Medical Center

Columbus, Ohio, United States

Outcomes

Primary Outcomes

carotid intimal media thickness (CIMT)

CIMT measurements will be performed at baseline (within 3 months of starting statin) and at 6, 12, 18, and 24 months. Change in CIMT is considered a surogate measure of atherosclerotic progression.

Time frame: 2 years

Data from ClinicalTrials.gov

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