Genetic Influences on Statin Blood Concentrations in African Americans

Ohio State University501 enrolled

Overview

This study intends to determine the effects of genetic polymorphisms on statin response and daily systemic exposure (24-hour area under the time-concentration curve) of statins in African-American patients.

Study Type

OBSERVATIONAL

Enrollment

501

Conditions

Hyperlipidemia Hypercholesterolemia Dyslipidemia

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * African-American patients taking a statin metabolized by CYP3A (e.g., atorvastatin, simvastatin, or lovastatin) Exclusion Criteria: * Age less than 18 years

Locations (1)

The Ohio State University Medical Center

Columbus, Ohio, United States

Outcomes

Primary Outcomes

24-hour area under the time-concentration curve of statin concentrations in plasma

Time frame: 2 years

Secondary Outcomes

Incidence of statin-associated muscle symptoms (SAMS)

Time frame: 10 years

Data from ClinicalTrials.gov

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