Hormonal Stimulation in IUI Treatment: Is Clomifen Combined With Ethinyl Estradiol Better, Worse or Equal to Menopur

University Hospital, Gasthuisberg371 enrolled

Overview

What is the best medication for hormonal stimulation in cycles with high intra-uterine insemination: tablets of Clomifen (5 days) followed by tablets of Ethinyl Estradiol (5 days) or daily injections with Human Menopausal Gonadotropin (Menopur)?

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

371

Conditions

Subfertility

Interventions

Clomifen, Ethinyl EstradiolDRUG

starting on day 2 or 3 of the cycle: 1 tablet of Clomifen each day, for 5 days in a row. Dose 50mg or in subsequent cycles, 25 mg or 100 mg or 150 mg. After the 5 days of Clomifen, one tablet of Ethinyl Estradiol 50 mg per day, for 5 days in a row or until beta hCG is injected

MenotropinsDRUG

Starting on day 2 or 3 of the cycle, a daily subcutaneous injection of 37.5 IU or 75.0 IU

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 42 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * women younger than 42 years old * infertility of at least one year * normal tubal, pelvic and uterine anatomy * semen with total motility count of at least 5 million (at least one sample) Exclusion Criteria: * premature ovarian failure * medical history of tubal or ovarian surgery * tubal or pelvic adhesions

Locations (1)

Leuven University Fertility Center

Leuven, Vlaams Brabant, Belgium

Outcomes

Primary Outcomes

pregnancy rate

Time frame: on average 30 days if not pregnant and 12 weeks if pregnant

Data from ClinicalTrials.gov

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