European Sapheon™ Closure System Observational ProspectivE (eSCOPE) Study

Inclusion Criteria: * Age ≥18 years and ≤ 70 years of age. * Symptomatic primary Great Saphenous Vein "GSV" incompetence diagnosed by clinical symptoms, with or without visible varicosities, and confirmed by duplex ultrasound imaging. * CEAP classification of C2, C3 or C4. * Ability to walk unassisted. * Ability to attend follow-up visits. * Ability to understand the requirements of the study and to provide written informed consent. * "GSV" on standing pre-procedure Doppler Ultrasound ≥3mm and ≤10mm (maximum diameter). Exclusion Criteria: * Life expectancy \< 1 year. * Regular pain medication. * Anticoagulation including Heparin or Coumadin. * Previous Deep Vein Thrombosis "DVT". * Previous superficial thrombophlebitis in "GSV". * Previous venous treatment on target limb. * Known Hyper-coagulable disorder. * Conditions which prevent routine vein treatment like: * Acute disease, * Immobilization or inability to ambulate, and * Pregnancy. * Tortuous "GSV", which in the opinion of the Investigator will limit catheter placement. (no 2 primary access sites allowed). * Incompetent ipsilateral small saphenous or anterior accessory great saphenous vein. * Known sensitivity to the cyanoacrylate "CA" adhesive. * Current participation in another clinical study involving an investigational agent or treatment, or within the 30 days prior to enrollment.