Should the dose of sugammadex in morbid obese patients be calculated on the real body weight or the ideal body weight? The main objective of the trial is to compare in patients undergoing bariatric surgery the efficacy of sugammadex to obtain a TOF-ratio of 100% within 3 min when dosing is based on real body weight (control intervention) with dosing based on ideal body weight (experimental intervention). The research hypothesis is that both dosing regimens are equivalent The secondary objective of the trial is to compare the impact of the depth of neuromuscular blockade on the surgical conditions: deep block (TOF-count 1 - 3) will be compared with very deep block (TOF count = 0 and PTC \< 5)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
34
2 mg/kg sugammadex (based og ideal body weight)
2 mg/kg sugammadex (based on real BW)
4 mg/kg sugammadex (based on real BW)
4 mg/kg sugammadex (based on ideal BW)
CHU Strasbourg Hôpital Civil
Strasbourg, Alsace, France
CHU Nancy
Vandœuvre-lès-Nancy, Lorraine, France
100% TOF-recovery 3 min after sugammadex
Time frame: 3 min
impact of depth of block on surgical conditions
to evaluate the impact of neuromuscular blockade on surgical conditions, the The "King Score" (King M, Anesthesiology 2000; 93:1392 - 7) will be applied every 15 min throught surgery by the surgeon (blinded to the study protocol)King-Score: from 1 to 4 with 1 excellent conditions, 2 good conditions, 3 acceptable conditions and 4 poor conditions.
Time frame: every 15 min during surgery
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