Feasibility, Safety and Efficacy of Remote Ischemic Preconditioning for Symptomatic Intracranial Arterial Stenosis in Octogenarians

Inclusion Criteria: 1. age between 80 to 95 years old 2. Trial of Org 10172 in Acute Stroke Treatment-1 (TOAST-1) subtype 3. National Institutes of Health Stroke Scale (NIHSS) score 0-15, and Modified Rankin Scale (mRS) score 0-4 4. ABCD2 score between 6 to 7 5. stable vital signs, normal hepatic and renal functions 6. no hemorrhagic tendencies Exclusion Criteria: 1. within 72 hrs of intra-artery or intravenous thrombolysis 2. intracranial hemorrhage or large area of cerebral infarction (more than 1/3 middle cerebral artery perfusion territory) 3. any soft tissue, orthopedic, or vascular injury, wounds or fractures in extremities which may pose a contraindication for application of the preconditioning cuffs 4. acute myocardial infarction 5. systolic blood pressure more than 200 mmHg after drug control 6. peripheral blood vessel disease 7. hematologic disease 8. severe hepatic and renal dysfunction 9. severe or unstable concomitant disease 10. cannot tolerate BLIPC or without informed consent