Phielix et al.: Hepatic Fat Content and Adipokines

German Diabetes Center24 enrolled

Overview

Thiazoledinediones decrease blood glucose by their insulin-sensitizing properties. Here the investigators examined whether pioglitazone (PIO) improves insulin sensitivity independently of glycemic control and whether adipokines or non-esterfied fatty acids (NEFA) serve as mediators.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Type 2 Diabetes Mellitus

Interventions

PioglitazoneDRUG

12 weeks of pioglitazone treatment

Eligibility

Sex: ALLMin age: 45 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * well controlled patients with type 2 diabetes (Hb1Ac \< 8%) * no insulin therapy * no co-morbidities * stable medication use for the last 6 months * stable body weight the last 6 months * no diet in the last 6 months Exclusion Criteria: * Hb1Ac \> 8% * insulin therapy * diabetes-related co-morbidities, like cardiovascular disease, neuropathology * unstable medication use * unstable body weight in the last 6 months (\> 5 kg) * following a diet in the last 6 months

Locations (1)

Medical University of Vienna

Vienna, Austria

Outcomes

Primary Outcomes

whole body insulin sensitivity

Participants underwent a two-step hyperinsulinemic euglycemic clamp to determine insulin sensitivity, expressed as rate of glucose disposal (Rd) in mg/kg/min.

Time frame: within a minimal of 1 week before the start of the 12 weeks pioglitazone or glimepiride treatment and after the last day of the treatment period.

Secondary Outcomes

intrahepatocellular lipid content

Liver proton-magnetic resonance spectroscopy was applied to determine liver fat (HCL) in % (relative to the water peak).

Time frame: within a minimal of 1 week before the start of the 12 weeks pioglitazone or glimepiride treatment and after the last day of the treatment period.

Data from ClinicalTrials.gov

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